Mids 6 on solo setting, treble slash tone, line 6 iv 75, metal red, drive 7.5 bass 5, mid 2, treble 9, channel vol 9.5 , reverb 7.5 , I adjust off of sweet child omine setting, to get that jcm 800 sound, and a gain pedal for leads, drive pedal for more crunch, n a boss wah wah, adjust the pedal a lil bit will get that slash tone, n yes the zebra Duncan pickups will give you a much brighter sound, try adjusting you pickups and pickup magnets for more hi end