I'm going to take it a little further as the Boss SY-300 is one of two indispensable pedals I now use with the Helix and I doubt I will ever need any more effects. Seriously....
The other pedal I use in conjunction is the Eventide H9. If there is something the line 6 can do, which isn't very much, then the H9 will cover it. It's the most comprehensive set of effects in a small box. Both pedals are really good at mangling the sound or as a doubler effect that is part guitar and part synth.
I have this set up so that if I use my feet, I can get different synth or h9 patches recalled with each Snap shot, so I 've greatly enhanced the number of different sounds I can get in a single set list. I have both stompboxes running with stereo outs in the chain and I drag the placement of the pedals around for different effects.
I can easily change parameters in either box , tied to the expression/foot-pedal that's included on the Helix. I made one spaced out strange wah patch using 3 signal paths, each with different wah and different settings , all triggered at the same time, as well as using the pedal to sweep across the filter cut on a synth sound, so it's a very strange and only possible with the Helix sound.
Lastly, I have learned how to use ableton live to automatically switch patches on the Helix, which in turn switch the patches of the other two pedals, to have electronic dance music that I perform live, with several different sounds and patches automatically triggered, no matter where I am on stage. Since guitar is practically a dirty word in Dance music, I have the ability to bring virtuosity to a dance music performance instead of a guy just standing there on a keyboard and can keep the actual guitar sounds to a minimum or nicely blended, while giving the audience the ability to watch my fingers play many main parts in real time, as well as really spacy sound effects. I've done this for psy trance and house, the latter allowing more funk based guitar sounds.
This could open up guitar players to playing in dance projects and not having to sit on the side quietly most of the time, the way Ronnie James Dio used keyboard players in his band....keyboard hardly ever playing and out of sight the whole gig.
For my rock band I just use the sy-300 for more subtle sounds, but I have a nice palette for intros and breakdown and people always ask me where the keyboardist is hiding, after a show.