I see that the Orange cr120 amp has an effects loop, which you'll of course want to be using with the 4cm. I have an old Crate vintage club 30 which has an effects loop, and referred to the video above when setting it up, and it works awesome. In my Helix presets I set up one of the foot switches to switch between Helix preamps and the Crate preamp, and switch between the two a lot, depending on the song. The Helix effects I have before the two preamp choices can be used by either of the two, and the post preamp effects (delays, etc...) can also be used by either one. I also have one foot switch dedicated to switching the channels on the Crate, and use that a lot also. I enjoy having so many options available, and to be able to switch between old school tube amp and modern Helix technology with the press of a switch. I've encountered no noise problems with my setup.