Hi, I've been using my KOT pedal sometimes in the in/out loop (might take it off if the new version with the KOT model sounds the same, though) and it works well. I didn't opt for the four jack option because I don't need to have another pedal in the middle. It's an interesting idea to have the Helix allow you to select either/or but you'd have to ask yourself if you plan to have the KOT on your board (where you can just hit the buttons if that's your plan) or in a rack well behind where you are playing. So, I guess I'm not really helping you much in that area lol. In terms of the high gain options, I went with the high gain ONLY on the red side when I bought mine years ago. The 'slightly less gain' on the right side works really well as a boost with a little bit of overdrive. Nobody is going to run a boost side turned way down so going with the high gain might give you a little more flexibility. I hadn't considered that when I bought it, kind of wish I had. I keep mine at around 1 o'clock all the time and it sounds just the way I need it. The higher gain side sounds incredible when you have that extra boost. The pedal is a lot like an amp - once you get the sweet spot set you'll probably almost never mess with it. Maybe a little tone adjustment if you switch from a single coil to a hum bucker, I suppose. One interesting note - I can get an identical tone from the Klon (compared to the KOT) that is already in the Helix. I guess those pedals must sound a lot alike. A friend of mine who tours with major acts has both the Helix, the Klon and a KOT and he said the same thing. He doesn't bother using anything other than his Helix anymore. He doesn't even use amps. His last tour grossed $266.1 million (so you can probably figure our who he's supporting, too bad he's 'only' a hired gun!) so I guess the Helix is all you really need. I'd still buy the KOT though since it's cool and you might as well since you waited so long.