As someone who migrated for a 500x nearly 10 years ago, with good (for the Pod) presets for every song, I can definatively say the settings do not translate between the two units. Not even close.
Unfortunately, you're up for a learning curve.
Fortunately, once you get it, the Helix will sound better, you'll create new patches faster, and may be more consistent. I found myself constantly tweaking most of my patches on the 500x, where as now I do minor adjustments when required, or when I think of a new way to do something want to try a new feature in a release.
My suggestions to get up to speed:
Spend a fair amount of time looking at Jason Saddites videos
[Edit] Check out highly rated patches on custom tone - but be prepared to modify to taste/guitar and playing style
Grab a small number of commercially available presets and see how they've been put together (I used Jason's, Marco Fanton, and Glenn DeLaune)
Create your patches from scratch and be prepared to use different amps effects and even order them differently to the 500x
Save often (not new)
Backup often (new)
Save favourite settings of amps and effects for reuse, and then modify as you learn more
Save template(s) of your approach to smooth workflow
Your next challenge will be patch leveling... but thats for later.