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Attached are 2 example presets. Example 1 is the usual way that it's done. Guitar>Helix INPUT Helix SEND 1>5150 INPUT 5150 SEND>Helix RETURN 1 Helix 1/4" LEFT MONO OUT>5150 RETURN Helix XLR LEFT MONO OUT>EVH Hypersonic INPUT If you want to use a Helix amp in addition or in place of the 5150's Preamp you can either place the Helix amp adjacent to the FX Loop with both Bypass assigned to a FS with FX Loop SAVED ON/Helix amp OFF (FS toggles 5150/Helix) as in example 1 or place the Helix amp on the Path 2B Split in front of the Cab as in the second example. There's lots of ways to do this, but in your configuration I think that using 1/4" for your 5150 and XLR for the FRFR would work best. sozorox1.hlx sozorox2.hlx