We've had some reports of Spider Remote 2.0 failing to launch or crashing on Windows 10 systems. This does not affect all Windows 10 systems. If you encounter this issue, we suggest that you ensure that the latest version of the .net framework from Microsoft is installed on your computer. If it is and you still are having trouble, try reinstalling/repairing your Microsoft Visual C++ redistributable.
Some users have found it helpful to install the most current version of C++ Redistributable, as well as both versions of the Visual C++ 2013 version:
Visual C++ 2013 Redistributable x86
Visual C++ 2013 Redistributable x64
If that does not help, please contact our support staff at Line6.com/company/contact.