I plug my HD500 straight into my BillM heavily modified Blues Jr. No effects loop, plug straight into the amp. Make SURE the HD front panel swithes near the volume foot pedal are on "Amp" and NOT "Line/Studio". If you don't put it on "Amp", you will be clipping the input to the Fender, and it will sound like crap. Also, make sure the switch that says "pad" is NOT on "pad", I can't remember the other setting. I get a buzzy hum from that setting when my guitar volume knob is all the way down. I use full amp models to my BJ as well, but make sure you are hitting the Fender with too hot of a signal first. Good luck HD500 takes some tweaking and knowledge of its quirks and gain stages, but I am really happy with mine.