I feel your pain on this topic, for me the biggest change in getting the tone I was looking for was using parallel IR blocks and setting the low cut and high cut on them. I play it through a Firehawk1500 and the amp sound is there for me. I can download another preset that sounds good on YouTube and through my setup it is terrible to me. Best advice I can give is decide on how you will play most of the time and concentrate on making that sound the way you want it to. Global EQ and the Low/Hi cut adjustments are a good place to look at. Don't give up, it's there and waiting for you to find what works for you!