I'm definitely one to study and tweak, less so read! I work at a church of around 4,000 and we still had amp volume issues before. After going to radial boxes running to amps offstage I finally tried an HD500X. After a couple weeks of running it to an amp I tried going direct and haven't looked back. I've since purchased a Helix and JTV69S and both electric players run direct now through the two boards.
Nothing will be as easy as plugging into an amp and fiddling with some knobs but you are absolutely right about having such a wide sonic palate to draw from with the modeling stuff. More often than not, the people listening can't tell the difference anyway. In fact, most guitar players can't either!