If I’m at small bars clubs and I don’t plug into foh, I just go with the preset speaker combo that worked during rehearsal with my band. If on bigger stages or I do run foh, I step off stage with wireless to see which mic I think might sound best in my preset and any other minor tweaks needed thru house PA system. Remember mics in the preset only work when you use the xlr out to foh. They don’t work when your just listening to yourself playing thru the Pc. I’ll turn my pc volume completely off to just here house pa tone for tweaking. I always use my PC as my monitor tilted towards me if using foh. Or backline if used not hooked up to foh. Oh, if you use ir’s there is no mic selection for xlr out. Or at least the one I have. Amp sound tone is pretty much same as tone coming out xlr. One last thing, I used to run my setup thru an atomic clr neo. For me the Powercab is better.