Hi,
My name is Chris. I've been using Line 6 PODs for 5-6yrs.
Its all about your personal guitar style and what kind of sounds you are looking to get. Its all about also how you like to use analog pedals too.
I could share you some of my tones, but you really can't beat learning to tweak and find sounds you like yourself. I like styles like Hillsong/Jesus Culture/SRV/John Mayer/U2 and the tones I have are based around those styles.
I run 3 main patches and from bank to bank just change the amp, thereby changing the style of the patch. (1. Rhythm, 2. Worship (some ambience and long delays), 3. Volume swells).
I have a JHS Morning Glory which compresses and drives which goes before the POD HD500, -> Red Comp which are both always on then depending on the heaviness of the tone I want, I have a tube screamer and a classic distortion going into the front of an amp, then usually one delay out of 3 delays (sometimes stacking them, depending on how much delay the sound I want needs). To turn any tone into a lead tone, I have a EX-1 which turns up the drive of the amp and I turn on all the drive pedals.
The only difference between my rhythm patch and my worship patch is I use a Cave Reverb and longer delays with more mix. Then my Volume Swell patch uses a particle verb instead of a cave reverb.
Bottom line is, you really can't substitute time messing around with the POD to see what sounds you like. I try and copy artists styles and try and adapt them to my own playing style.
I hope this has helped. Any questions please ask and let me know if you'd like to see one of my patches.
Chris