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After over 10 hours of installing and reinstalling I finally managed to get the USB Driver to install and run. Problem: Workbench installs fine Line 6 Monkey installs and updates fine but reports no USB Driver Windows Device Manager reports corrupted or incompatible driver when usb interface is plugged in The solution: Click Start, Type Core, Select Core Isolation and run, turn off the Memory Integrity then reboot. The driver then miraculously functions fine. Line 6, please pin this somewhere as it was incredibly hard to find a solution and please see if the issue can be addressed.
Just spent a few frustrating days trying to get Line 6 usb drivers for Helix and Variax to load successfully. Admittedly I hadn't connected either to my PC for a while, so a lot could have changed in that time. To cut a long story short, the resolution for me has been to turn off Memory integrity in Core isolation in the Windows Defender Security Centre. Neither my audio interface nor phone had problems, so in my limited sample set only the Line 6 drivers were struggling. Is this a known phenomenon? Should the drivers load with Memory integrity enabled? In both cases the drivers are the current versions (220.127.116.11 and 18.104.22.168 for Helix and Variax respectively). I tried earlier Helix drivers but they had the same problem. My OS is Windows 10 Home, Version 1803.