Actually on my asus rog laptop Ive headed the similar problem, but in my case line6 drivers somehow affected thundelbolt ports/controller which refused to initialize properly
, after Ive uninstalled it, the problem was solved, the issue with thundelbolt ports appeared after I've waked up my laptop , despite power for usb ports/controllers was turned to be always on, the driver version was 4.2.7.6. cuz 4.2.7.7 caused bsod after some time of working in my daw (~30 min)/
So temp solution could be to disable memory integrity/core isolation as well as unplug hd500x before putting your PC to sleep, choose the proper driver as well, never let it go to sleep for saving power, but it could be really helpful to have some update on drivers/firmware from line6
If any of current employers of line6 is reading this, could you pls give us something more compatible to the latest windows version, like beta driver or smth?