I have the same issue with Windows 8 Pro x64.
I have tried every single solution mentioned it this thread, but nothing seems to work for me.
When the sound drops I'm not even able to restart the PC from Windows - when I press Restart, Windows hangs on the Restarting and rotating circle screen!
Only pressing the reset button on my PC helps.
Line 6, you have to find a fix for this, because I think the UX 2 driver is causing these problems..
So, now I'm back to Windows 7 till they'll fix it!