I've had my Amplifi for about a week now. I don't have any of my iTunes music on my iPad because I only use it for music creation. You don't have to use tone matching if you don't want to. You can create tones just like you can with any other Line 6 pod device. The only difference is that you can use the touch screen to edit, which is very nice.
One of the reasons music developers always flock to Apple is because all of the tools for music are built into the OS. Whether it's iOS or OSX, core midi and core audio are built into the operating system. This makes things so much simpler for software developers when creating music software, especially when it needs to communicate with an external device (i.e. midi keyboard controller, audio interface, etc.) I'm not sure, but I have a feeling that adjusting parameters on the amp requires midi. Even if it doesn't, using an existing protocol like midi sure simplifies things.
I'm not sure about the audio/midi capabilities on Android. Does it have anything comparable to core audio/core midi built in?
As far as the sound, the Amplifi sounds pretty darn amazing for the price range!