I have encountered this problem too. I believe it's called 'knob jitter'... Almost every time I used a footswitch or even looked at my unit the wrong way, the settings on the amp would change, usually the treble and/or drive knobs in my case.
The recommended solution is to set all knobs to zero. It works on my HD500. After I save my preferred settings, I zero all the knobs, click out of that patch then back in again. Rock steady.
It's possibly a hardware problem, so a warranty replacement might be a good idea. One forum post I read claimed it could be resolved at the software level by changing the tolerance to physical knob movements caused by slight bumps.
All the best!