Yes...I do this by assigining an input,...say guitar for the first line....and a specifis output....I have in that line a send command to an output that i am not using...say send 4.....I do tha same for the second line...input might be return 1....output, XLR....or what ever you choose....and also have in that line the same send command ....send 4 in this case.... as in the first line....then. I put the output levels of that “send 4” commands to as low as possible....Then to snapshots....Snapshot 1....I have the Send 4 off for line 1. And on for line 2...Snapshot 2...I have Send 4 on for line 1 and off for line 2....switching snapshots switches lines....