When using the RETURN, setting the MODE Switch to "Power Amp In" bypasses everything**, sending the signal direct to the Power Amp.
You can also use the "FX Loop" position, which allows you to use any of the Cat's FX that are placed in the POST position.
I use it this way when using the Cat with my HX Stomp to free up blocks/dsp on the HXS.
**Poorly documented is the Fletcher-Munson EQ compensation applied to the Power Amp in the .5db attenuator setting.
This provides a fuller sound at low volume by boosting specific low and high frequencies.
Also, the overall Output Level at ALL attenuator settings is further attenuated by (IIRC) 6db when the MODE Switch is in the "Power Amp In" position.
I assume that this is to accommodate preamps/multifx that have only a LINE Level output. Helix/HX multifx outputs can be set to either INSTRUMENT (as expected by most guitar amp FX Loops) or LINE.
While you CAN, of course, use IRs when using the Cat's RETURN, I have gotten mixed results.
The Catalyst is NOT a FRFR speaker, it is a "Special Design" Eminence guitar speaker.
An IR is, functionally, simply a specific EQ curve designed to mimic a specific guitar speaker/cab combination.
If it SOUNDS GOOD TO YOU, then go for it.
However, the speaker is NOT DESIGNED to be used with IRs. It is a guitar speaker designed to sound good with a range of amp types in an open back cab.