I use my Helix with a 65 fender twin head to marshal 4-12 cab and use the preamps as tone modules.
Note: it has taken a little while to dial in some sounds that I really like,but for me thats just half the fun.
To me the Helix is a tool and there are no rules to creativity.BTW....this thing is a blast and I 've already
used it in the studio.......My creative 2 cents
David