I have a JTV, POD HD Pro, DT 25 Head and an L3t. The sound from the POD into the L3t is as good to my ear as with the DT25, which is why I have made the decision to sell my DT25. I love my JTV59 - it is the guitar I play most these days, at the expense of a PRS and EBMM JP6.
Therefore, if I were in your position, I would choose the JTV and play 'direct' to PA with the POD. Yes, PA's can vary wildly, but if you're micing up a DT25 then that will be subject to similar variability in the PA. If you want the most versatile solution, the JTV is the way to go (alternate tunings, acoustics etc, etc..)
If you do decide to go the DT25 route and are in the UK, feel free to contact me ;-)