I think it works in any combination. But as noted previous, you need to tweak according to your setup. I don't think there is any right or wrong way to do it. I personally use the L2T speakers for live and rehearsal, but at home I am plugged into my PC and studio monitors....and sometimes one of the L2T as well :)
For my application I can pretty much go between monitors and the L2T speakers as they are both flat reference, you most definitely would have to tweak separate patches for monitors and then another for integration with your amp set up. But isn't that half the fun?