There are a lot of tutorials for the "milton cleans" just follow those and translate to the helix. The trick Acle uses often is not using an amp model at all.
The distorted tone Tesseract uses is just boosted 5150 I believe. The trick will be in the eq. Again there are a lot of tutorials online...just translate to helix.
As for the precision drive, you say it's in the loop surely you are running it before the amp block in the helix correct? This is also probably a source of the "buzz" the gate on the pedal should help. Some people go nuts with gates for this type of sound but I do just fine with one(isp decimator) between my OD and amp. I haven't messed with the helix gates much but I'm sure one of them is similar enough.
My advice would be to ditch the precision drive at first and just see how close you can get with the helix alone. Once you get close with that then you can sort out adding the external pedals. I'd go tubescreamer, gate, 5150, IR, and I usually throw eq block in front and at the end of the chain.