Yes and no... ebfore I relate my experience, what guitar are you using?
I'm not a Helix user, yet - still mulling it over.
My 'rig' is Mesa Triaxis based rack setup. I usually play a custom made ESP HSS Strat-a-like through it. Despite the gear appearance, I'm NOT a metal player, I can assure you. I roll between clean to bluesy levels of OD, I guess and as you should expect with the amount of dough spent, it sounds incredible.
Now, I'm not getting any younger and I don't play 'the rig' at home. A few months back, I 'treated' myself to an Epiphone Dot. Yeah, it's cheap, but it plays well and I can't really justify a couple of grand for the real thing, just for home. I play it through a Vox AC4TV and it sounds pleasant enough. It's had pots and caps, picikup adjustments and improved massively. New pickups made a slight difference...
Anyhoo, speaker went in one of 'Deep Thought's' cabs a few weeks back, so decided it was time for a change in them and bought a pair of V30s.
Installed, in my living room, connected everything up and grabbed the nearest guitar - the Epi...
Hells Teeth!!! That thing sounds devastating.
Moral of the story, if your guitar sounds 'Meh', don't waste money on pickups. Get a better amp.
Another one, FWIW, I use a 'well known amp simulation plugin' in my DAW and get a really good bass sound by feeding the DI through an 'AC30' with a 'EL34' power stage and a 4x15 cab - an approximation of an AC50, I think.