Yes, I had overlooked the FRFR part in my earlier response. The AI directions seem correct to me as far as they go. But I think it has overlooked the desire to use either the real amp or an amp sim at any time.
You still need the amp sim block after the FX Loop and you need to arrange for it to be bypassed when the FX Loop is on. You will need to use a Split block after the amp sim with a Cab/IR after the Split to provide cab simulation to the FRFR. I would use the 2nd Output block rather than a Send block for the FRFR signal. The signal entering the Split block should have either the amp’s preamp or the amp sim, not both. Choose/configure the Split block to send the signal through to both paths. One path goes to the amp’s cab while the other goes through a cab sim to the FRFR.
Set up your presets to use either your amp’s preamp or an amp sim, not both. For your amp’s preamp activate the FX Loop, and deactivate it for the amp sim. If you want to get really fancy and use either the amp’s preamp or an amp sim in the same preset you might look into using Snapshots to activate or bypass the FX Loop and the amp sim with one footswitch.