Understanding the Jangle box and where it comes from is the key.
The Jangle Box was created to help attain that jangly tone immortalized by certain recordings such as The Byrds Tambourine Man & Turn Turn Turn. That sound can also be found on the Beatles (Ticket to Ride, Hard Days Night, You Can't Do That, etc... etc...) & Fast forward 15 years or so and that tone was prominent again with Tom Petty and the Heartbreakers on many recordings.
Important distinction. The Jangle Box did not create those tones, it makes it easier for guitar players to re-create those tones.
The Studio Way:
IMO, the best option for getting these in the Helix is to do it like they did it in the studio
Guitar > Amp (often a Vox for Jangle) > LA Studio Comp
Set the basic guitar and amp tone without the compressor turned on... you want a normal warm/rich tone at this stage, do not try to simulate the "jangle" tone at this stage.
Set the LA Studio Comp for a high peak reduction, then play with the emphasis to bring out the highs and lows as required.
It's the copious amount of "peak reduction" and "high end emphasis" from the Studio Comp that creates the jangle from the normal guitar tone you started with.
The Stomp Box Way:
This may be a simpler approach, especially if you don't have a solid grasp on studio style compression... or just prefer a basic stomp box.
Stomp Style Compressor > Guitar > Amp (often a Vox for Jangle)
Do not turn the compressor on yet.... start by getting a warm/rich tone on your guitar amp... don't try to get the jangle there.
Now... what compressor to use
The Jangle Box is a derivative of the Dyna Comp you could just use one of the many Dyna Comp options in the Helix then add an EQ after it to emphasize the highs to bring them out. NOTE: The upcoming Helix 2.8 update will include a TILT EQ... this will be a perfection "simple" EQ option to bring out the HIGH or LOWS as needed. It would be very similar to the "emphasis" control on the LA Studio Comp I mention above.
Don't discount the legacy "Blue Comp" or "Blue Comp Treble".... Based on the BOSS CS-1 this comp would behave like the Jangle box in it's "treble mode". IMO... I prefer to have more control over the treble than just an "on/off" state, but that's just a preference.
Just my thoughts on the subject... I'm sure others may have a few more ideas for you.