I used to use the 4 pedal mode (I think that's what it is called... top four button for effects, bottom four for patch change)... however I have changed to the 8 button mode (again the name? sorry... all eight buttons are assigned to an effect)... For the lead boost, i use the EQ pedal and just give it a db boost... nothing else. I also like to use a tube screamer and then tube drive in the same line. I can go from clean (screamer off, drive off) to light crunch (screamer on, drive off) crunchier crunch (screamer off, drive on) and smooth driving lead (screamer on, drive on) ... I can then hit the EQ boost if I need extra volume. I really like this setup. I also like to have two delays, short and long in the same line..
My train is this Vetta Comp -> Throaty Wah -> Tube Screamer -> Tube Drive -> Analog Chorus -> Lux Nrm Pre Amp -> Mixer -> Short delay -> Long Delay
I have the pedal set to control the volume of the amp which saves me from adding a volume pedal to the chain.