The amount of latency in the configuration you describe will be miniscule, maybe 6-8ms. Even if you're using wireless it will still be just at the 10ms average threshold of perception. Each AD/DA conversion takes <>2ms, so:
G10 wireless - PG = 2ms
PG - HXFX - = 2ms
HXFX - PG = 2ms
HXFX end to end = 2ms?
PG end to end = 2ms?
I'm not actually sure about the end to end numbers, as they somewhat depend on what FX are used.
Unless you're Steve Vai (claims to be able to feel 2ms, but uses digital FX...), it won't be a problem.