A few things that I've found that help:
Finding a good all-arounder amp model for the music you play and using snapshots and controller assignments in stomp mode to modify gain, eq, ir, and volume to help reduce the amount of effects blocks eating up DSP.
Using a Pre EQ before the amp block rather than a tightening overdrive, and modifying your own IR's and loading them into your Stomp rather than post-EQ blocks in your chain.
Using one effect for two things like the 3 Band Comp for EQ+Comp or a Delay with a level parameter boosted for leads with delay