I bought a Helix just to see what it can do. I am 1.5 weeks into my 30 days, if I want to return it. So far I've gone back and forth a few times. The deeper I dig, though, the more I like it.
I've still got my pedalboard - TC Small Polytune > JRockett Small Blue Note > Strymon Riverside > EHX Soul Food > Barber Tone Press > Source Audio Gemini Chorus > Source Audio Nemesis Delay > Strymon Flint > Strymon TimeLine > Strymon Deco.
The first order of business was to try and simulate my effects. The Helix falls a little short when it comes to things the TimeLine, Deco and Nemesis can do, so I hope they really beef up the delays in it. It's also a little flat in the reverbs department. Halls are kinda not up to snuff compared with Halls on other platforms. The drives in the Helix though are wonderful. I am not a FUZZ user, but do like overdrives and distortions occasionally. I primarily play clean, though.
I am not as concerned about modeling amps as I am about finding something that sounds good to me. I now play through a Quilter MicroPro200 Mach2 8" combo which is great. That's the right side of my stereo setup. A Carr Raleigh is the other side.
I have found that simply playing with amps, cabs, IRs, and room Reverbs can get me several amp sounds I like that are different enough from each other as to merit using them.
I've not used Helix live yet, having just moved to the Chicago area. I don't really have a situation that would work. But I plan on programming the Helix and taking a thumb drive with me to my old home city to sit in with my old band, renting a Helix and a pair of FRFRs, and using that wherever I play. That way, I just have to carry a guitar.
Hopefully, that plan will work!
Bob