Based on the minimal information that you provided, I suggest using wires.
I know, smartass response, but without specific goals, how can anyone possibly suggest any more than that?
Start by reading the Helix manual to understand its capabilities.
Then, draw a diagram of your desired audio and MIDI signal flows.
If you do both of those you will probably be able to answer most of your questions and you will then be able to formulate specific questions that we might be able to address.