Helix, PC212+, Scarlett 18i20, Ext HD, Printer, Wireless Mouse, 4 MIDI controllers (KB, eDrums, nanoKontrol for DAWs, Grid controller for LIVE! - oh, yeah, I forgot the FCB1010 - that's 5 MIDI/11 USB total) .
No monitors though.
The Helix is connected to the PC212+ by L6 Link, and the PC212+ Outs are connected by XLR to the Scarlett. The Scarlett also connects back to the PC212+ to get amp sims into it.
There's a G10 wireless connected to the Helix by 1/4" to AUX (for bass, main guitar is cabled to Guitar IN), and the G10 XLR goes to the Scarlett (for dry tracking and amp sims).
Laptop audio out goes to the Scarlett also so I can get backing trax and streaming audio sources into the DAW.
The Helix and Scarlett USB go straight to the laptop, everything else connects either to the powered hub or the USB C hub (regular USB ports connected to the laptop by C Port).
The trick for me was to connect the external HD to the USB C hub and all the MIDI controllers and the Mouse dongle to the powered hub. Blessed silence!
Naturally, after trying EVERY USB in EVERY port, with and without the Isolator, the ext HD to USB C hub was the last thing I tried.....