Sorry, but your headline is wrong: It works on my MBP mid 2014 with USB 3 (DAW and the Amplify 150 is shown in the Line 6 Updater).
What kind of Mac (Model, Year) do you use? Perhaps it's a problem with Macs built after 2014 as yapruder also wrote above. It doesn't seem a problem having to do with USB3 and Macs in general.